The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
Veterans Affairs promotes suicide prevention hotline - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

1.50 Veterans Affairs promotes suicide prevention hotline

Last week, the Department of Veterans Affairs put up nearly 1,200 advertisements on city buses, bus shelters, rail and subway stations across the nation displaying a message of hope for those who have served their country and may be facing an emotional crisis. The VA will be promoting its suicide prevention hotline through Jan. 9, 2011. Links to the transit advertisements and PSAs are available for download via YouTube.

For more information , view the taking life saving campaign to streets at

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