The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
Suicide more likely after brushes with the law, Reuters, Feb. 8, 2011 - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

9.09 Suicide more likely after brushes with the law, Reuters, Feb. 8, 2011

According to research appearing in Archives of General Psychiatry this month, people who come into contact with the criminal justice system – including those who are never held in custody and those who are found not guilty– are at increased risk for suicide. The researchers examined data on more than 27,000 Danish men and women who died by suicide between 1981 and 2006, and compared it to data on half a million people of the same age and gender who were still alive. About a third of men who had killed themselves had ever been charged with a criminal offense, compared to only a quarter of men in the comparison group. Among women, almost one in eight who had died by suicide had been in contact with the criminal justice system, compared to only one in 20 women who were still alive. The new research expands on previous studies of jail inmates and suicide, which found that prison inmates are up to nine times more likely than members of the general population to die by suicide.

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