The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
Soldiers with mental illness more often get PTSD, Reuters, May. 2, 2011 - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

5.52 Soldiers with mental illness more often get PTSD, Reuters, May. 2, 2011

The results of a new study published in Archives of General Psychiatry may have implications for preventing post-traumatic stress disorder (PTSD) among members of the military. The study was based on a survey of more than 22,000 soldiers who completed a health questionnaire before and after deployment to Iraq or Afghanistan. Before deployment, just over three percent had some mental illness, such as depression or panic disorder. Upon return, eight percent of soldiers had developed symptoms of PTSD, and those who had mental illness (other than PTSD) before deployment were more than twice as likely to have developed the condition. “More vulnerable members of the deployed population might be identified and benefit from interventions targeted to prevent or to ensure early identification and treatment of postdeployment PTSD,” wrote the study authors.

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