The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
Sheriff Cabral to Hold Press Conference Related to Markoff Suicide - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

2.58 Sheriff Cabral to Hold Press Conference Related to Markoff Suicide

Suffolk County Sheriff Andrea J. Cabral plans to hold a press conference at 4 p.m. today to discuss policies and procedures at Boston’s Nashua Street Jail, including the requirements of correctional officers conducting checks on inmates.

The sheriff’s public comments come amid ongoing questions about the suicide of inmate Philip Markoff, the so-called Craigslist killer, who was found dead in his cell at the jail Sunday morning. Cabral has so far declined to discuss how Markoff was being monitored on Sunday morning. He had been on suicide watch before.

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