The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
Safe and effective messaging for suicide prevention - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

2.55 Safe and effective messaging for suicide prevention

A 2-page document that offers evidence-based recommendations for creating safe and effective messages to raise public awareness that suicide is a serious and preventable public health problem is now available. It contains Do’s and Don’ts for creating public messages for suicide prevention and is useful when working with the media.

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