The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
New programs reach out to seniors touched by loss - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

2.56 New programs reach out to seniors touched by loss

According to Yeates Conwell, co-director of the Center for the Study and Prevention of Suicide at the University of Rochester, “many [elderly people] feel that once they reach the nursing home, their lives are worthless because they’re not able to contribute to society.” This article discusses the issues of isolation, loss and depression that can affect older Americans and focuses on some of the programs and treatments that can help them remain engaged and productive. Read the full article at

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