The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
Maternal or Paternal Suicide and Offspring's Psychiatric and Suicide-Attempt Hospitalization Risk - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

1.50 Maternal or Paternal Suicide and Offspring’s Psychiatric and Suicide-Attempt Hospitalization Risk

This research published October 2010 in Pediatrics found that maternal suicide is associated with increased risk of suicide-attempt hospitalization for offspring, beyond the risk associated with maternal accidental death. However, paternal suicide is not associated with suicide-attempt hospitalization. Future studies should examine factors that might differ between offspring who experience maternal versus paternal suicide, including genetic or early environmental determinants.

Read the full article listed under publications at the American Academy of Pediatrics website,

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