The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
Laughter and Suicide - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

2.57 Laughter and Suicide

Accidents and suicide are the leading causes of death among young Native Americans. And brazen humor may get to the heart of the problem. The fight against the high rates of suicide among Indian people has found a seemingly unlikely champion in Lakota comedian J.R. Redwater. JR performed recently at Cankdeska Cikana Community College on the Spirit Lake Nation in North Dakota as part of their suicide prevention program. A member of the Standing Rock Sioux tribe, JR’s take-no-prisoners approach to poking fun at reservation life has a poignant ring of first hand experience. Clearly, as my auntie would have said, “he’s been dragged across a few floors,” in his life.

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