The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
Is the Recession Fueling a Suicide Epidemic? - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

2.58 Is the Recession Fueling a Suicide Epidemic?

New research suggests the nation’s unemployed are committing suicide at an alarmingly high rate.

“We won’t have nationwide suicide numbers for a year or two,” says Annie Lowrey in the Washington Independent . “there are ominous signs of a real spike” since the downturn hit. There’s a historical precedent, too: The suicide rate in the U.S. rose by 20 percent during the Great Depression.

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