The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
Insider: The DOD and Brass Don’t Know and Don’t Care about Suicides - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

2.58 Insider: The DOD and Brass Don’t Know and Don’t Care about Suicides

On July 29, the Army released its “Health Promotion, Risk-Reduction and Suicide Prevention Report,” the result of a 15-month effort, directed by Army Vice Chief of Staff Gen. Peter Chiarelli. Chiarelli explained to reporters at the Pentagon that the investigation that produced the report was prompted by the fact that in January 2009, the suicide rate in the Army hit 20 per 100,000 population, exceeding the civilian rate of 19 per 100,000 for the first time.

In addition to suicide, the report addresses other indicators of stress on the force, including high-risk behaviors, such as substance abuse, and the number of soldiers who enter the mental-health system voluntarily as well as involuntarily. Then it lays out what Chiarelli described as a “campaign plan” to try to drive down the suicide rate, and includes more than 250 recommendations in an attempt to identify and mitigate the problems that stem from “nearly a decade of persistent conflict.”

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