The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
IASP announces theme for World Suicide Prevention Day - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

6.38 IASP announces theme for World Suicide Prevention Day

The theme for the September 10, 2011 World Suicide Prevention Day observance, Preventing Suicide in Multicultural Societies, was selected to raise awareness of the fact that all countries are multicultural. This multicultural mix can include indigenous peoples, immigrant groups, refugees, asylum seekers, and others. While national strategies often target the majority population, specific cultural perspectives are often missing. Suicide prevention in multicultural societies requires cultural sensitivity as well as cultural competence. The International Association for Suicide Prevention (IASP) is providing materials, suggestions for events, and information on activities already planned throughout the world.

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