The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
Depressed teens mostly struggle alone, The Los Angeles Times, Apr. 29, 2011 - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

5.51 Depressed teens mostly struggle alone, The Los Angeles Times, Apr. 29, 2011

Survey results released by the Substance Abuse and Mental Health Services Administration (SAMHSA) show that about eight percent of American adolescents reported an episode of major depression in the preceding year, but only a third of those affected had received treatment. Teens who had suffered from a depressive episode were more likely to have misused prescription drugs or alcohol. According to SAMHSA Administrator Pamela Hyde, the findings underscore the importance of identifying and treating children’s mental health problems early, since treatment “can turn a life around and reduce the impact of mental illness and substance abuse in America’s communities.” The findings are from a national survey of drug use and health conducted in 2009. The survey also found that about 15 percent of teens said they had seriously contemplated suicide in the preceding year.

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