The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
CSN announces online forum CSN Communities - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

2.45 CSN announces online forum CSN Communities

The Children’s Safety Network (CSN) is proud to announce CSN Communities, an online forum for support and increasing awareness about the importance of injury and violence prevention. Through CSN Communities, state and territorial Maternal and Child Health (MCH) and Injury and Violence Prevention (IVP) staff can share resources, have an ongoing dialogue about their work, and talk with experts in the field of injury prevention.

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