The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
California : People in crisis have someone to call, The Walnut Creek Patch, Apr. 25, 2011 - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

6.06 California : People in crisis have someone to call, The Walnut Creek Patch, Apr. 25, 2011

This story about the Contra Costa Crisis Center in Walnut Creek, California illustrates the many different roles a crisis center may play in a community. The crisis center answers the county’s 24-hour crisis and suicide lines, as well as the grief, homelessness, child abuse, and elder abuse hotlines. The center also answers local calls to the National Suicide Prevention Lifeline and the Lifeline’s Spanish-speaking suicide hotline. In addition, the center’s youth services coordinator ran a support group for youth that helped 10 high-risk girls at a local high school improve their attendance and their grades. The Contra Costa center is one of six U.S. crisis centers participating in a suicide follow-up call program funded by the Substance Abuse and Mental Health Services Administration and tracked by researchers at Columbia University. As part of the study, callers to the Contra Costa crisis lines who are assessed to be at moderate to high risk of suicide are asked whether they would welcome follow-up calls. Callers who consent receive one or two follow-up calls from clinic staff to make sure they feel supported and are following the agreed-on safety plan. In 2010, the 85 volunteers at the Center answered 29,142 crisis calls, including 5,315 suicide crisis calls.

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