The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
Army suicides rise; prevention strategy changes, CBS News, Jul. 17, 2010 - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

2.41 Army suicides rise; prevention strategy changes, CBS News, Jul. 17, 2010

A new U.S Army suicide prevention video tells the true-life stories of soldiers who made suicide attempts or experienced serious psychological distress, and their friends and loved ones who helped them get the help they needed. The Army hopes that service members will find the new video more engaging than the previous version, which used actors instead of actual soldiers and their family members. Thirty-two active duty and reserve soldiers died by suicide in June, the highest monthly total on record.

Watch the video Shoulder to Shoulder: I Will Never Quit on Life

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