The relationship between the intracanular concentrations of unbound (free) furosemide and its natriuretic effect is in the form of a sigmoid curve with a minimum effective furosemide excretion rate of about 10 g / min. Therefore, prolonged infusion of furosemide is more effective than repeated bolus administration. In addition, if a certain bolus dose is exceeded, no significant increase in the effect is observed. When the tubular secretion of furosemide decreases or when the drug binds to the albumin located in the lumen of the tubules (for example, in a nephrotic syndrome), the effect of furosemide decreases.
A war inside: Saving veterans from suicide, e! science news, Jun. 30, 2011 - Suicide & Faith

Suicide Prevention in Faith Organizations: An Introduction

6.43 A war inside: Saving veterans from suicide, e! science news, Jun. 30, 2011

According to new research published in the journal BMC Public Health, veterans who have attempted suicide have an elevated risk of suicide compared to both military and civilian peers. The study analyzed data on 10,163 veterans treated for a suicide attempt between 1993 and 1998 and found that suicide was the second-leading cause of death among male veterans and the leading cause of death among female veterans. Compared to the general population, veterans also had three times the mortality risk from all causes. “The “healthy soldier effect” is no reason to think that veterans should be more emotionally and mentally resilient than anyone else,” said lead study author Douglas J. Wiebe, assistant professor of epidemiology at the Perelman School of Medicine at the University of Pennsylvania. “The consequences of military service can include both physical and emotional health challenges that veterans continue to face long after ‘their war’ is no longer on the front page.”

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